Crigler najjar syndrome


1month 5 days old yellow discolored infant brought to Homoeocare with reports showing:

 

At birth

24/3/17

3/4/17

11/4/2017

Total Serum Bilirubin

15.23

24.67

26.36

17.59

Serum Conjugated Bilirubin

0.41

0.73

0.64

0.54

Serum Unconjugated Bilirubin

14.82

23.94

25.72

17.05

 

At birth did phototherapy in view of jaundice. Due to persistent hypoglycemia, lethargy and hyperbilirubinemia newborn was shifted to NICU but there was no improvement; his bilirubin levels were continue to fluctuate. Very high level of unconjugated bilirubin i.e. severe jaundice present at birth or during infancy leads to diagnosis of Crigler-najjar syndrome. It  is an inherited disorder affecting metabolism of bilirubin. Hemoglobin breakdown into heme and globin; further heme decomposes into iron and biliverdin which later on convert into bilirubin. In liver these unconjugated bilirubin conjugates with glucuronic acid and forms conjugated bilirubin which is excreted into bile and urine. When there is impaired liver uptake, impaired conjugation or increased production of unconjugated bilirubin, it crosses blood-brain barrier causing damage of brain and nerve tissues.

After homeopathic treatment of Crigler-najjar syndrome at HomoeoCARE : Symptomatically infant was started to improve gradually; his eyes and face seemed to be less yellow.

 

27/5/2017

5/6/2017

13/12/2017

Total Serum Bilrubin

7.01

4.83

0.8

Serum Conjugated Bilirubin

0.35

0.3

0.4

Serum Unconjugated Bilirubin

6.66

4.53

0.4

 

27/11/2017:CT Scan of brain does not reveal any significant intracranial abnormality.



Post By: Dr-Admin


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