What is Crigler Najjar Syndrome?

Understanding Crigler-Najjar Syndrome

If your near and dear ones are suffering from some genetic disease like Crigler Najjar syndrome, don’t be disheartened. Homeopathic treatment for Crigler-Najjar syndrome offers effective management, reducing the impact of gene mutations for a better quality of life.

Crigler Najar Syndrome

A Battle Against Bilirubin Buildup

Crigler-Najjar syndrome (CNS) is a rare genetic disorder. It is caused by a mutation of the UGT1A1 gene. It is an autosomal recessive disease. Hence it is commonly seen in a consanguineous marriage.  Crigler Najjar syndrome affects the metabolism of bilirubin, hence causing an increase in levels of unconjugated bilirubin. 

What is Bilirubin?

Bilirubin is a yellow pigment, formed due to the breakdown of RBC. This unconjugated bilirubin (indirect bilirubin) is converted into conjugated bilirubin by the Liver. The Conjugated bilirubin is water soluble and can be easily excreted in the bile. 

In Crigler-Najjar syndrome, since the unconjugated bilirubin is not metabolized, the levels of bilirubin increase. These high levels of bilirubin cause damage to infants' brains.

Signs and Symptoms of Crigler Najjar Syndrome

The main symptom of Crigler-Najjar syndrome is jaundice. In jaundice, there is yellowing of the skin and eyes. In severe instances, elevated bilirubin levels can impact brain development and function, leading to:

• Drowsiness
• Lethargy
• Irritability
• Poor feeding
• Seizures
• Developmental delays

HomoeoCARE's Approach

In all genetic diseases, we have a specialized approach based on the research of Dr. Pravin Jain. First, we try to check the genetic reports of both the parents and the child. If the parent's reports are negative, then it seems that is a case of de novo mutation. This this scenario, we take the mother's history during pregnancy to find out the cause of the mutation.

If both the parent's geentic tests are posotive for the mutation, then we also take adidtional symptoms from the parent's history and wholistically analyse all the data.

This approach has helped HomoeoCARE to give better results in genetic diseases. With homeopathy, we can minimize the impact of genes on the brain and can some extent reverse the brain damage. One such case of Crigler Najjar syndrome came to HomoeoCARE and our team successfully handled him

HomoeoCARE's Success

A male child, aged 1 month and 22 days, was diagnosed with Crigler Najjar Syndrome. At birth, his bilirubin levels were very high (17.8). Initially, the doctors thought it to be physiological jaundice and he received phototherapy and was admitted in the NICU for nine days. However, his bilirubin levels did not become normal. His bilirubin levels kept increasing, and the doctors diagnosed as Crigler Najjar Syndrome. Conventional treatments failed to improve his condition, so the parents opted for homeopathic treatment at HomoeoCARE.

After starting the homeopathic treatment, within 2 weeks the child's bilirubin levels dropped from 26 to 17. It further improved from 7.01 and 4.8, and finally in six months returned to normal. The child’s general health also improved significantly. As his general condition improved, his developmental milestones were also improved. Now he is involved in activities typical for his age, such as riding a bicycle. This case highlights the effectiveness of homeopathic treatment for genetic conditions like Crigler Najjar Syndrome. The child's developmental progress shows no deficiency, indicating a complete return to normal activities and milestones